Search results for "cancer cell targeting"

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Ferritin-Coated SPIONs as New Cancer Cell Targeted Magnetic Nanocarrier

2023

Superparamagnetic iron oxide nanoparticles (SPIONs) may act as an excellent theragnostic tool if properly coated and stabilized in a biological environment, even more, if they have targeting properties towards a specific cellular target. Humanized Archaeoglobus fulgidus Ferritin (HumAfFt) is an engineered ferritin characterized by the peculiar salt-triggered assembly-disassembly of the hyperthermophile Archaeoglobus fulgidus ferritin and is successfully endowed with the human H homopolymer recognition sequence by the transferrin receptor (TfR1 or CD71), overexpressed in many cancer cells in response to the increased demand of iron. For this reason, HumAfFt was successfully used in this stud…

nanoparticleferritinOrganic ChemistrySPIONcoatingPharmaceutical ScienceSPIONs; cancer cell targeting; coating; ferritin; nanoparticlesAnalytical Chemistrycancer cell targetingSPIONsChemistry (miscellaneous)Drug DiscoveryMolecular MedicinenanoparticlesPhysical and Theoretical ChemistryMolecules

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PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
  - PE2_1Theory of fundamental interactions
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  - PE11_12Semi-conducting and magnetic materials engineering
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LSLife Sciences
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  - LS4_1Organ and tissue physiology and pathophysiology
  - LS4_4Endocrinology
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  - LS4_5Non-hormonal mechanisms of inter-organ and tissue communication
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  - LS3_8Embryogenesis, pattern formation, morphogenesis
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  - LS3_17Theoretical modelling in cellular, developmental and regenerative biology
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SHSocial Sciences and Humanities
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